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- W2393344103 abstract "AIM To investigate the protective effect and possible mechanism of total flavones from Dracocephalum moldavica pretreatment on myocardial ischemia-reperfusion injury in rats.METHODS Myocardial ischemia-reperfusion model was established on rats by ligation of coronary artery.S-T segment change was recorded and the histopathological changes were observed.The activities of lactate dehydrogenase(LDH),creatine kinase(CK),creatine kinase isoenzyme(CK-MB),acetic transaminase(AST),total superoxide dismutase(T-SOD),glutathione peroxidase(GSH-Px),myeloperoxidase(MPO) and the level of malonaldehyde(MDA),nterleukins-1(IL-1),nterleukins(IL-6),tumor necrosis factor-α(TNF-α) in serum were detected.RESULTS Compared with model group,the experiment revealed that total flavones from Dracocephalum moldavica attenuated S-T segment elevation and myocardium pathological changes decreased the activities of LDH,CK,CK-MB,AST,MPO and the level of MDA,IL-1,IL-6,TNF-α in serum,and improved the activities of T-SOD and GSH-Px.CONCLUSION The experiment shows that total flavones from Dracocephalum moldavica present protective effects against ischemia-reperfusion injury in rats,and its mechanism is probably related to resist oxidation damage and inflammatory reaction." @default.
- W2393344103 created "2016-06-24" @default.
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- W2393344103 date "2013-01-01" @default.
- W2393344103 modified "2023-09-23" @default.
- W2393344103 title "Protective effect of total flavones from Dracocephalum moldavica against myocardial ischemia-reperfusion injury in rats" @default.
- W2393344103 hasPublicationYear "2013" @default.
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