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- W2393372246 abstract "Objective To investigate the inhibitive effect of Sanjiayigan granule(SJG) on carbon tetrachloride(CCl4)-induced hepatic fibrosis in rats,and approach the mechanism of prevent experimental hepatic fibrosis by SJG.Methods Fifty male SD rats were randomly divided into three groups.The rats in model group(n=18) and SJG group(n=17),40% CCl4 solution diluted by peanut oil were given by subcutaneous injection two times a week to establish hepatic fibrosis model,meanwhile,SJG and distilled water were given by intragastric administration to the rats in the SJG group and the model once a day respectively.The rats in control group(n=15),normal saline were only given subcutaneously,two times a week,and distilled water were given by intragastric administration once a day.Hepatic tissue were collected at end of 6th and 8th week respectively.The histological changes of liver were examined.The expressions of procollagen typeⅠand type Ⅲ mRNA were measured by reverse transcriptase-polymerase chain reaction(RT-PCR).Results In SJG group,the degeneration,necrosis,inflammation and fibrosis in hepatic tissue decreased obviously compared with the model group in the corresponding time period(P0.01).In the SJG group at the 6th week,hepatic fibrosis in portal areas,central veins and some thin fibrous intervals were observated.However,the structure of liver lobules was still maintained.In the SJG group at the 8th week,there were some thick fibrous septas in some slices,but not pseudolobules.The expressions of procollagen typeⅠand Ⅲ mRNA in the model group increased obviously compared with the normal group(P0.01),it decreased obviously in the SJG group compared with the model group(P0.01).Conclusion The SJG can lighten necrosis and inflammatory reaction in liver,and inhibit the expressions of procollagen type Ⅰand Ⅲ mRNA in rats.So it can decrease the degree of experimental hepatic fibrosis." @default.
- W2393372246 created "2016-06-24" @default.
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- W2393372246 date "2009-01-01" @default.
- W2393372246 modified "2023-09-23" @default.
- W2393372246 title "Inhibition of Sanjiayigan granule on expressions of procollagen typeIand III mRNA in hepatic fibrosis rats" @default.
- W2393372246 hasPublicationYear "2009" @default.
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