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- W2393389628 abstract "Objective To investigate the correlation between clinicopathological parameters and the expressions of inhibitor of differentiation/DNA binding 3 (Id3), vascular endothelial growth factor (VEGF) and human epidermal growth factor receptor-2 (HER-2/C-erbB-2) in patients with breast cancer. Methods The protein expressions of Id3, VEGF and C-erbB-2 were detected by SABC immunohistochemistry in 70 spceimens of breast cancer, 40 specimens of tissue adjacent to breast cancer, 20 specimens of fibroadenoma and 20 specimens of normal breast tissue. Results The expressions of Id3, VEGF and C-erbB-2 in breast cancer tissue (88.6%, 95.7% and 20.0%, respectively) were significantly higher than that in the other tissues (P0.01). No statistical correlation existed between the expressions of Id3, VEGF and C-erbB-2 among the patients as grouped by age, lymph nodes metastasis, tumor size and histological grading (P0.05), while the expression of C-erbB-2 protein substantially varied among the patients of breast cancer in different pTNM stages (P0.05). Spearman rank correlation analysis revealed that the expression of Id3 was positively correlated with that of VEGF (r=0.367, P=0.002), whereas the expression of C-erbB-2 was negatively correlated with that of estrogen receptor and progesterone receptor (r=-0.335, P=0.005 and r=-0.300, P=0.012, respectively). Conclusions Over-expressions of Id3, VEGF and C-erbB-2 exist in the patients with breast cancer. C-erbB-2, which is negatively correlated with the expressions of estrogen receptor and progesterone receptor, may serve as an important reference for prognosis of breast cancer. The expression of Id3 is positively correlated with that of VEGF." @default.
- W2393389628 created "2016-06-24" @default.
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- W2393389628 date "2009-01-01" @default.
- W2393389628 modified "2023-09-24" @default.
- W2393389628 title "Expression of Id3,VEGF and C-erbB-2 and clinical significance in patients with breast cancer" @default.
- W2393389628 hasPublicationYear "2009" @default.
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