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- W2393395223 abstract "bjectives:To investigate the effects of 4 human inhibin(hIn)α fragments on basal hCG and FSH induced progesterone(P_4)production by rat corpus luteal(CL)cell;and the role of protein kinase A(PKA)signal system in their action.Design:An in vitro culture study.Setting:Reproductive Endocrinology Laboratory in Harbin Medical University.Methods:Superovulation and luteinization of the follicles were induced in immature(25～28day)Wistar rats by subcutaneous injection of 65IU PMSG,followed bv 35IU hCG.CL cells were dispersed by Collagenase-DNase and cultured in KRBGAL solution,4 in the medium were measured by RIA after 2 hrs incubation.Results:Four hIn α fragments,P￣(22),P￣(32),P￣(32)-Tyr,and p￣(29),were synthesized.The 4 hin a fragments all caused signifcant decrease in basal P_4.With the exception of p￣(22),the other three fragments at the dose of l00 ng all attenuated the FSH(0.02 IU)and hCG(0.2 IU)stimulated P_4.It was further shown that 4afragments all inhibited the P_4,stimulated by l00 nmol/L Forskolin,20 nmol/L dbcAMP,and l0μg PKA,significantly.Forskolin and FSH significantly stimulated P4 production,but Forskolin conbined with FSH caused inhibitory effect on P_4,and this action was enhanced by hIn α fragments Concl usion:The inhibitory action of hIn α on P_4 production by rat CL cells could possibly throughthe act on the receptor,cAMP and PKA level,resulting in reduction of progesterone." @default.
- W2393395223 created "2016-06-24" @default.
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- W2393395223 date "1996-01-01" @default.
- W2393395223 modified "2023-09-25" @default.
- W2393395223 title "The effect of 4 synthetic human inhibin alpha fragments on progesterone production by rat corpus luteal cells and its relation to protein kinase A system" @default.
- W2393395223 hasPublicationYear "1996" @default.
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