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- W2393399992 abstract "AIM To study the expressions of HSPs in epidermal keratinocytes of pre and post treatmental psoriatic lesions. METHODS We detected the expressions of HSP27 and HSP70 in epidermal keratinocytes of pre and post treatmental psoriatic lesions (25 cases) and normal control skins (6 cases) by means of immunohistochemical LSAB method and the Color Medical Image Analysis System (CMIAS). RESULTS HSP27 and HSP70 were expressed constitutively in epidermal keratinocytes of nomal skins (HSP27 0.100± 0.015 A ; HSP70 0.094±0.018 A ). In epidermal keratinocytes of psoriatic lesions, the expressions of HSP27 and HSP70 were very weak, and even negative (HSP27 0.068±0.028 A ; HSP70 0.034±0.014 A ). The differences were significant between 2 groups ( P 0.05). The expressions of HSPs were increased gradually in epidermal keratinocytes after treatment (HSP27 0.105±0.028 A ; HSP70 0.078± 0.022 A ). But the differences of expression of HSPs in epidermal keratinocytes were not significant among different therapies. CONCLUSION Expressions of HSP27 and HSP70 are negative in epidermal keratinocytes of psoriatic lesions, increased gradually with treatment. HSPs may play an important role in stress protective mechanism of psoriasis." @default.
- W2393399992 created "2016-06-24" @default.
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- W2393399992 date "2001-01-01" @default.
- W2393399992 modified "2023-09-28" @default.
- W2393399992 title "Significance of expression of heat shock proteins in epidermal keratinocytes of psoriatic lesions" @default.
- W2393399992 hasPublicationYear "2001" @default.
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