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- W2393402368 abstract "Objective To develop a model of lacunar infarction based on selective endothelial damage of perforating artery and thrombotic occlusion in situ of small arterial injury in rats.Methods 100 μg of sodium laurate was injected into the right internal carotid artery of SD rats on days 1 and 3. The consequences of ischemic brain damage were examined by histopathological analyses and three behavior tests.Results Five hours after the first injection of sodium laurate, microscopic examination of phosphotungstic acid hematoxylin-stained sections revealed that fibrin fibrils obstructed the perforating arteries in the ipsilateral hemisphere. Transmission electron microscope examination revealed the damage of capillary endothelial cells,edema of astrocytes process and pyknosis of neurons in the ipsilateral hemisphere. No evidence of endothelial cell damage of the middle cerebral artery could be found in the ipsilateral side.72 hours after the second injection of sodium laurate,most rats in the model group showed behavior change and there was significant difference as compared with sham-operated group (P0.01). Luxol fast blue-HE-stained sections revealed multiple small cerebral infarcts in the cortex, hippocampus, and thalamus.Conclusion This model is useful to investigate the pathophysiology and clinical treatment of lacunar infarction caused by perforating arterial occlusive diseases." @default.
- W2393402368 created "2016-06-24" @default.
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- W2393402368 date "2003-01-01" @default.
- W2393402368 modified "2023-09-23" @default.
- W2393402368 title "The development of cerebral lacunar infarction model in rats" @default.
- W2393402368 hasPublicationYear "2003" @default.
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