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- W2393419524 abstract "Aim: To investigate the effect of exogenous HCAP1 gene products on apoptosis and apoptotic related proteins Bax and Bcl-2 in Burkitt lymphoma cell line Raji. Methods: HCAP1 gene was transfected into the Raji cells by the medium of liposome. The cell apoptosis was examined by means of flow cytometry and Hochest 33258 fluorescein staining. The levels of apoptotic related proteins Bax and Bcl-2 were measured by Western blot. Results: The percentage of apoptotic cells was significantly increased in the Raji cells transfected with HCAP1, as compared with the Raji cells transfected with PBK/CMV empty vector, at 24,48 and 96 hours after transfection. Western blot showed the expression ratio of the Bax to the Bcl-2 was increased. Conclusion: Overexpression of HCAP1 gene could induce apoptosis of the Raji cells. The upergulation of the expression ratio of Bax to Bcl-2 may be involved in the pathway of apoptosis induced by HCAP1 gene." @default.
- W2393419524 created "2016-06-24" @default.
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- W2393419524 date "2003-01-01" @default.
- W2393419524 modified "2023-09-25" @default.
- W2393419524 title "Effects of HCAP1 on apoptosis and apoptotic related proteins Bax/Bcl-2 in Raji cells" @default.
- W2393419524 hasPublicationYear "2003" @default.
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