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- W2393424755 abstract "Objective To study the age-related changes of rat bone histomorphometry and its correlation to other parameters of bone metabolism. Methods Ten female SD rats at the age of 3 months old,9 months old and 15 months old were labeled with tetracycline(30 mg/kg) via abdomen on fourteen and four days before executing. Histomorphometry were performed on L4 and right tibiae. Physical density of left femur and L2 were measured. Anti-compression property of L3 was assayed. Serum levels of calcium and phosphorus and 1,25(OH)_ 2 D_ 3 were determined. Results Compared with the 3-month-old rats,the trabecular bone volume(TBV) of L4 and right tibiae decreased 43.3%( P 0.01)and 28.0%( P 0.01),respectively in 15-month-old rats;Formation surfaces(FS) of lumbar and femur decreased 17.2%( P 0.05),Resorption surfaces(RS) increased 39.8%( P 0.01),Bone density(BMD) decreased 7.7% ( P 0.01) and 7.3%( P 0.01),respectively. Compared with the 3-month-old group,maximal load,maximal stress and modeling volume respectively decreased 53.8%( P 0.01),53.7%( P 0.01)and 33.2%( P 0.01) in 15-month-old group. Serum 1,25(OH)_ 2 D_ 3 declined 28.6%( P 0.05)in 9-month-old group and 34.1%( P 0.01)in 15-month-old group. A positive correlation was found between TBV and lumbar vertebrae BMD( r =0.684,P 0.001),serum 1,25(OH)_ 2 D_ 3 (r=0.866,P 0.001),maximal load( r =0.972,P 0.001),maximal stress( r =0.971,P 0.001) and modeling volume( r =0.971,P 0.001). There were also a positive correlation between serum 1,25(OH)_ 2 D_ 3 and FS( r =0.587, P 0.01) and mineral apposition rate(MAR)( r =0.628, P 0.01). Conclusions The bone formation was decreased while its resorption was increased;the bone mass was declined and its micro-structure was changed in fifteen-months-old rats. There exists a significant correlations between the histomorphometic parameters and BMD,and biomechanical parameters." @default.
- W2393424755 created "2016-06-24" @default.
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- W2393424755 date "2004-01-01" @default.
- W2393424755 modified "2023-09-22" @default.
- W2393424755 title "Age-related changes of rat bone histomorphometry and its correlation to other parameters of bone metabolism" @default.
- W2393424755 hasPublicationYear "2004" @default.
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