Matches in SemOpenAlex for { <https://semopenalex.org/work/W2393431635> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2393431635 endingPage "6" @default.
- W2393431635 startingPage "571" @default.
- W2393431635 abstract "Iron plays a key role in Parkinson s disease (PD). To illustrate the mechanism underlying the increase of iron in substantia nigra (SN) in PD, changes of the expression of divalent metal transporter 1 (DMT1) and iron content were examined in SN in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated mice using immunohistochemistry and histochemistry respectively. Following MPTP treatment for 3 d, elevated iron staining was found in SN. A further increase in iron content was observed after 7 d. In these lesioned animals, tyrosine hydroxylase-immunoreactive DA neurons exhibited a decrease in number and morphological changes as well. There were two isoforms of DMT1 expressed in SN of mice. After MPTP treatment, the expression of DMT1 without IRE form increased in either group, whereas DMT1 with IRE form increased only after 7 d of MPTP treatment. These observations suggest that DMT1 is possibly involved in the process of iron accumulation in SN of MPTP-treated mice, which might be responsible for the subsequent death of DA neurons." @default.
- W2393431635 created "2016-06-24" @default.
- W2393431635 creator A5018682241 @default.
- W2393431635 creator A5031516698 @default.
- W2393431635 creator A5065416738 @default.
- W2393431635 date "2003-10-25" @default.
- W2393431635 modified "2023-09-27" @default.
- W2393431635 title "[Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice]." @default.
- W2393431635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14566406" @default.
- W2393431635 hasPublicationYear "2003" @default.
- W2393431635 type Work @default.
- W2393431635 sameAs 2393431635 @default.
- W2393431635 citedByCount "16" @default.
- W2393431635 countsByYear W23934316352012 @default.
- W2393431635 countsByYear W23934316352014 @default.
- W2393431635 countsByYear W23934316352015 @default.
- W2393431635 countsByYear W23934316352016 @default.
- W2393431635 countsByYear W23934316352017 @default.
- W2393431635 countsByYear W23934316352018 @default.
- W2393431635 countsByYear W23934316352021 @default.
- W2393431635 crossrefType "journal-article" @default.
- W2393431635 hasAuthorship W2393431635A5018682241 @default.
- W2393431635 hasAuthorship W2393431635A5031516698 @default.
- W2393431635 hasAuthorship W2393431635A5065416738 @default.
- W2393431635 hasConcept C104317684 @default.
- W2393431635 hasConcept C126322002 @default.
- W2393431635 hasConcept C134018914 @default.
- W2393431635 hasConcept C137183658 @default.
- W2393431635 hasConcept C149011108 @default.
- W2393431635 hasConcept C159167319 @default.
- W2393431635 hasConcept C185592680 @default.
- W2393431635 hasConcept C204232928 @default.
- W2393431635 hasConcept C2776531687 @default.
- W2393431635 hasConcept C2778674702 @default.
- W2393431635 hasConcept C2780938664 @default.
- W2393431635 hasConcept C513476851 @default.
- W2393431635 hasConcept C55493867 @default.
- W2393431635 hasConcept C71924100 @default.
- W2393431635 hasConcept C86803240 @default.
- W2393431635 hasConceptScore W2393431635C104317684 @default.
- W2393431635 hasConceptScore W2393431635C126322002 @default.
- W2393431635 hasConceptScore W2393431635C134018914 @default.
- W2393431635 hasConceptScore W2393431635C137183658 @default.
- W2393431635 hasConceptScore W2393431635C149011108 @default.
- W2393431635 hasConceptScore W2393431635C159167319 @default.
- W2393431635 hasConceptScore W2393431635C185592680 @default.
- W2393431635 hasConceptScore W2393431635C204232928 @default.
- W2393431635 hasConceptScore W2393431635C2776531687 @default.
- W2393431635 hasConceptScore W2393431635C2778674702 @default.
- W2393431635 hasConceptScore W2393431635C2780938664 @default.
- W2393431635 hasConceptScore W2393431635C513476851 @default.
- W2393431635 hasConceptScore W2393431635C55493867 @default.
- W2393431635 hasConceptScore W2393431635C71924100 @default.
- W2393431635 hasConceptScore W2393431635C86803240 @default.
- W2393431635 hasIssue "5" @default.
- W2393431635 hasLocation W23934316351 @default.
- W2393431635 hasOpenAccess W2393431635 @default.
- W2393431635 hasPrimaryLocation W23934316351 @default.
- W2393431635 hasRelatedWork W1982922725 @default.
- W2393431635 hasRelatedWork W2014817776 @default.
- W2393431635 hasRelatedWork W2024262458 @default.
- W2393431635 hasRelatedWork W2030745669 @default.
- W2393431635 hasRelatedWork W2036972872 @default.
- W2393431635 hasRelatedWork W2123684032 @default.
- W2393431635 hasRelatedWork W2147426990 @default.
- W2393431635 hasRelatedWork W2393431635 @default.
- W2393431635 hasRelatedWork W2418845751 @default.
- W2393431635 hasRelatedWork W2961144956 @default.
- W2393431635 hasVolume "55" @default.
- W2393431635 isParatext "false" @default.
- W2393431635 isRetracted "false" @default.
- W2393431635 magId "2393431635" @default.
- W2393431635 workType "article" @default.