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- W2393440432 abstract "Aim The expression of NF-κB activation and the effect of antioxidant (N- acetylcysteine, NAC) on NF-κB activity in human airway epithelial cell was assessed. Methods Using the TNF-α,the airway epithelial cell strains of normal subject(16HBE) and tumor patient (H292) was activated and using Western-Blot and ELISA the expression of NF-κB and IL-8 were detected. Results It was found that the activity of NF-κB could be stimulated by the TNF-α and increase with the amount of TNF-α with the peak occurring at 2 to 4 hours after stimulation and then decreasing at six hours. At the same time, the level of IL-8 was elevated, but decreased with inhibition of NF-κB activity by NAC, that means the action of NAC has a dose-dependent effect. Conclusion NAC not only blocks the signal transmission activated by NF-κB, but also anticipates the transcription modulation of expression of many cell factors and inflammatory mediums. It suggests that NAC may play a role in the anti-inflammatory treatment of respiratory diseases." @default.
- W2393440432 created "2016-06-24" @default.
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- W2393440432 date "2000-01-01" @default.
- W2393440432 modified "2023-09-23" @default.
- W2393440432 title "Activation of NF-κB in airway epithelial celland modulation mechanism of NAC" @default.
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