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- W2393461207 abstract "Objectives To investigate the effects of valsartan on the expression of FAS and FAS-L in hyperthyroid cardiomyopathy rats.Methods New sprague-dawley rats were randomly divided into four groups(n=10 each): control group,L-thyroxine group(L-thyroxine alone),valsartan low dose group(L-thyroxine + valsartan 10 mg/kg) and valsartan high dose group(L-thyroxine + valsartan 30 mg/kg).Rat models of hyperthyroidism were established by daily intraperitoneal injections of L-thyroxine[0.5 mg/(kg·d)] in L-thyroxine group and valsartan groups for 28 days.At the same time,rats in valsartan low dose group received gastric lavage treatment of valsartan 10 mg/(kg·d),and rats in valsartan high dose group were drenched with valsartan 30 mg/(kg·d).Intravenous blood samples were collected before and after model establishment and plasma levels of TT3 and TT4 were measured by chemiluminescence method.All the rats were treated for 4 weeks,and at the end of the treatment,cardiac mass index was determined.Ventricular tissue was collected for hematoxylin-eosin(HE) and masson stains.Cardiomyocyte diameter,collagen volume fraction and structural changes were obtained..Protein expression of FAS and FAS-L in left ventricle was localized by immunohistochemistry and semi-quantified by pathological image analysis system.Results Compared with control group,cardiac mass index,cardiomyocyte diameter,collagen volume fraction and protein expression of FAS and FAS-L in L-thyroxine group significantly increased(P0.05).Cardic mass index,cardiomyocyte diameter,collagen volume fraction and protein expression of FAS,FAS-L significantly decreased in valsartan groups(P0.05).There were no significant differences of the above indexes between valsartan low dose group and valsartan high dose group(P0.05).Conclusions Valsartan can effectively inhibit ventricular remodeling,ameliorate myocardial hypertrophy by decreasing the expression of FAS/FAS-L." @default.
- W2393461207 created "2016-06-24" @default.
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- W2393461207 date "2013-01-01" @default.
- W2393461207 modified "2023-09-26" @default.
- W2393461207 title "Effects of valsartan on expression of FAS/FAS-L in experimental cardiomyopathy rats induced by levothyroxine" @default.
- W2393461207 hasPublicationYear "2013" @default.
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