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- W2393493244 abstract "ObjectiveTo investigate the mechanism of CO X-2 and Bcl-2 and genes in carcinogenesis of colorectal carcinoma and adenoma.Methods The expression of COX-2 and Bcl-2 were detected by i mm umohistochmically in colorectal cancinomas and 28 colorectal adenomas and 10 nor mal colorectal tissue.Apoptosis cells were detected by TUNEL. ResultsThe positive expression of COX-2 were 75 0%、78 6% a n d 0 0% respectively and the positive expression of Bcl-2 were 71 4%、39 3% a nd 20.0% respectively in colorectal caicinomas、adenomas and normal tissue.Expressi on of COX-2 and Bcl-2 was not significant difference in colorectal carcinomas an d adenomas (P0 05).But expression of both were higher than normal tissue (P0 01).Apoptosis index was much higher in colorectal caicinomas than in colorectal adenomas(χ 2=8.80, P0 05) .The expressions of COX-2 an d Bcl-2 were reversely correlated to apoptosis index(ademomas,P0 01;Carcinoma s,P0 05).Their expressions were not associated with clinical pathological features of colorectal carcinoma.Apoptosis index was not associated with clinic al pathological features of colorectal carcinomas(P0 05) ConclusionOverexpression of COX-2 and Bcl-2 in colorectal ad en oma and carcinoma may indirectly promote the carcinogenesis of colorectal cancer as an important gene inhibiting cell apoptosis,COX-2 and Bcl-2 play an import ant role in tumor development and progression." @default.
- W2393493244 created "2016-06-24" @default.
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- W2393493244 date "2003-01-01" @default.
- W2393493244 modified "2023-09-26" @default.
- W2393493244 title "Expression of COX-2 and Bcl-2 genes in colorectal carcinoma and adenoma" @default.
- W2393493244 hasPublicationYear "2003" @default.
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