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- W2393501073 abstract "Objective:To explore the effect of isatin on substantia nigra(SN) BAX gene expression in MPTP-induced PD model in mice.Methods:C57BL/6J mice were divided into 5 groups:① control group;② MPTP group;③ ISA 50 mg/kg ig + MPTP group;④ ISA 100 mg/kg ig + MPTP group;and ⑤ ISA 200 mg/kg ig + MPTP group.Then immunohistochemical techniques was used to observe the BAX gene's expression in substantia nigra in each mouse.Results:The results showed that compared with the control group,the BAX immunoreactive expression in SN was higher in MPTP injury mice(P0.01);in ISA 100 mg / kg and 200 mg / kg pretreatment group,the BAX immunoreactive expression in SN was significantly reduced compared with the MPTP injury group(P0.05).Conclusion:It is shown that the ISA has the protective effect on MPTP-induced PD model in mice." @default.
- W2393501073 created "2016-06-24" @default.
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- W2393501073 date "2011-01-01" @default.
- W2393501073 modified "2023-09-25" @default.
- W2393501073 title "Effects of isatin on substantia nigra BAX gene expression in MPTP-induced PD model in mice" @default.
- W2393501073 hasPublicationYear "2011" @default.
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