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- W2393504528 abstract "Objective To investigate the association between promoter-1118C T polymorphism of MEK5 gene and the susceptibility to sporadic colorectal cancer(CRC).Methods MEK5-1118C T genotypes were determined by Taqman-MBG probes in 703 healthy controls and 737 patients with CRC,and the findings were analyzed epidemiologically.Results The rates of drinkers and smokers were significantly higher in CRC group than in the control group(P 0.05).No significant distribution of MEK5-1118C T between the patients with CRC cases and the control subjects was observed(P 0.05).But the genotypes(T + CC)of-1118C T variants had a trend of increase in the risk of sporadic CRC(OR = 1.42,95%CI = 0.97 ～ 2.08,P 0.05).Further more,the interaction between-1118C T variant genotypes and fatness(BMI≥24 kg /m2)and drinking increased the risk of CRC(OR = 1.73 and 1.19,95%CI = 1.24 ～ 2.42 and 1.04 ～ 1.37,P 0.01 and 0.05).Conclusions Drinking and smoking are independent risk factors for sporadic colorectal cancer in southern Chinese population.MEK5-1118C T polymorphism has no significant relation with sporadic colorectal cancer,but the interaction between variant genotypes and drinking and fatness is an increased risk of colorectal cancer." @default.
- W2393504528 created "2016-06-24" @default.
- W2393504528 creator A5014946926 @default.
- W2393504528 date "2013-01-01" @default.
- W2393504528 modified "2023-09-23" @default.
- W2393504528 title "Association of MEK5 gene promoter-1118C > T polymorphism with risks of sporadic colorectal cancer" @default.
- W2393504528 hasPublicationYear "2013" @default.
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