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- W2393527698 abstract "Objective To explore the distribution features of gene polymorphism of Methylenetetrahydrofolate reductase(MTHFR)C677Tand A1298Cand methionine synthetase reductase(MTRR)A66Gin Han females from Linyi City.Methods A cross-sectional study was conducted to survey 1403Han females from Linyi City by collecting oral mucosal epithelial cells to extract genomic DNA and then to perform MTHFR and MTRR gene polymorphism examinations with a Taqman-Minor Groove Binder method.The distribution features of genetic polymorphisms was analyzed and compared with the results from other reports on different areas.Results The MTHFR 677TT homozygotic mutation genotypic frequency in Han females from Linyi City was 32.90%,which was higher than that in Guangdong Province,Hainan Province,Zhenjiang city in Zhejiang Province and Zibo City in Shandong province(P 0.01).The MTHFR 1298CC homozygotic mutation genotypic frequency in was 2.3%,,which was lower than that in Guangdong Province, Hainan Province and Jiangsu Province(P0.01).The MTHFR MTRR 66CC homozygotic mutation genotypic frequency was5.9%,which was lower than that in Guangdong Province and Hainan Province(P 0.05). Conclusion The distribution of MTHFE and MTRR polymorphisms in Han females from Linyi City have regional specificity and the MTHFR 677TT homozygotic mutation genotypic frequency was high.Determination of MTHFR gene polymorphism can be used to guide the individualized acidum folicum supplementing to reduce birth defect." @default.
- W2393527698 created "2016-06-24" @default.
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- W2393527698 date "2013-01-01" @default.
- W2393527698 modified "2023-09-25" @default.
- W2393527698 title "THE DISTRIBUTION FEATURES OF GENE POLYMORPHISMS OF MTHFR AND MTRR IN HAN FEMALES FROM LINYI CITY" @default.
- W2393527698 hasPublicationYear "2013" @default.
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