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- W2393536616 abstract "Objective: To evaluate the effects of cytochrome P-450 2D6*10(CYP2D6*10) genetic polymorphism on the postoperative patient-controlled analgesia with morphine in HAN population.Methods: Totally 64 patients in grades I – II by American Society of Anesthesiologists(ASA) grading were enrolled in this study,among which 56 patients completed the experiment.Patients were categorized into three groups according to the CYP2D6 genotype: wild homozygote(w/w group,n = 19),heterozygote(m/ w group,n = 21) and mutation homozygote(m/m group,n = 16).After receiving a loading dose(i.v.0.1 mg/kg) in 10 min before the end of operation,patients could conduct patient-controlled analgesia(PCA) by self administration of morphine(one time 1 mg) via self-controlled infusion pump.Blood samples were collected after induction of general anesthesia.The CYP2D6*10 genotyping was conducted by means of polymerase chain reaction-based restriction fragment length polymorphism(PCR-RFLP).The total consumption of morphine and the visual analogue score(VAS) for the three genotype groups within 72 h after the operation were recorded and compared.Results: The cumulative dose of morphine in CYP2D6*10 m/w group was significantly higher than that in the m/m group at T0.5 ～ 4 h(P 0.05).There was no signifcant difference of VAS among three groups within 72 h after the operation.Conclusion: The current results suggested that CYP2D6*10 m/w group appeared to require more morphine in the acute operative period(0.5 ～ 4 h after operation) compared with CYP2D6*10 m/m group.One possible mechanism for this observation is that CYP2D6*10 m/w group may have lower effciency in synthesizing endogenous opioid peptide compared with CYP2D6*10 m/m group." @default.
- W2393536616 created "2016-06-24" @default.
- W2393536616 creator A5057555537 @default.
- W2393536616 date "2013-01-01" @default.
- W2393536616 modified "2023-09-23" @default.
- W2393536616 title "EFFECTS OF CYTOCHROME P-450 2D6*10 GENETIC POLYMORPHISM ON THE POSTOPERATIVE PATIENT-CONTROLLED ANALGESIA WITH MORPHINE IN HAN POPULATION" @default.
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