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- W2393545630 abstract "Objective To investigate the relationship between plasma apelin-12 level and hypertension,obesity,insulin resistance(IR),inflammation of type 2 diabetes mellitus(T2DM). Methods 25 healthy subjects of control group,30 T2DM patients,38 patients with T2DM and hypertension were selected. The plasma levels of apelin-12,tumor necrosis factor-α(TNF-α),blood fat,glycosylated hemoglobin(HbA1c),fasting plasma glucose,fasting insulin level,IR index(HOMA-IR),body mass index(BMI) and blood pressure were measured in each group. Data were analyzed by variable correlation. Results ① The apelin-12 levels in patients with T2DM and hypertension were significantly lower than that in control and T2DM groups(P0.05 or P0.01),the apelin-12 level of patients with T2DM group was higher than that in control group (P0.05).②TNF-α levels in patients with T2DM and hypertension was significantly higher than that in control and T2DM groups(P0.05 or P0.01),TNF-α level of patients with T2DM only was significantly higher than that in control group(P0.05).③There were negative correlation between the plasma apelin-12 level and WHR,FINS,HOMA-IR,TG,SBP,TNF-α,and positive correlation between it and the HDL-C. WHR,HOMA-IR,TG,TNF-α were equal predicators of plasma apelin-12 level. Conclusions The plasma level of apelin-12 is increased in T2DM group and decreased in T2DM with hypertension group.Apelin-12 is correlated with obesity,IR and inflammation. A speculation can be drew that the apelin-12 may contribute to the development of IR,T2DM and hypertension." @default.
- W2393545630 created "2016-06-24" @default.
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- W2393545630 date "2010-01-01" @default.
- W2393545630 modified "2023-09-25" @default.
- W2393545630 title "The relationship between plasma apelin-12 level and hypertension,insulin resistance of type 2 diabetes mellitus patients" @default.
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