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- W2393554531 abstract "Objective To assess the protective effects of GM 1 ganglioside on cerebral cellular respiratory function, and to study the ultrastructure changement after traumatic brain injury in rat model. Methods Sprague Dawley rats were divided into three groups: normal group, 0 9% sodium chloride solution treated control group and GM 1 treated group. Results The results showed R 3(oxygen uptake rate in state 3 respiration), RCR(respiratory contral ratio) and P/O(the molar ratio inorgenic phosphate esterified and oxygen reduced), OPR(oxidative phosphoxylation rate) decreased significantly in contral group on 8th and 16th hour after injury, while increaed dominantly in GM 1 treated group, which were similar to those in normal group. Cortical neurons and their mitochondrial ultrastructure of control group were severely damaged, while the pathological changes in GM 1 treated group were much milder. Conclusion The possible mechanism is that GM 1 keeps normality of the plasma membrane lipids, and membrane enzyme activity, and reduces ionic imbalance, edema and free radical formation." @default.
- W2393554531 created "2016-06-24" @default.
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- W2393554531 date "1999-01-01" @default.
- W2393554531 modified "2023-09-22" @default.
- W2393554531 title "Protective effects of GM 1 ganglioside on cerebral cellular respiratory function and ultrastructure after traumatic brain injury" @default.
- W2393554531 hasPublicationYear "1999" @default.
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