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- W2393559092 abstract "OBJECTIVE To investigate the role of protein kinase C(PKC) in mediation of ischemic preconditioning(IPC) against myocardial reperfusion injury by using PKC inhibitor polymyxin B(Poly B) and PKC activator 4β-phorbol-12-myristate-13-acetate(PMA) during cardiopulmonary bypass(CPB) in feline.METHODS One hundred and twenty felines were randomized into five groups: control group(n=24),in which CPB was conducted without aortic cross-clamping(ACC);IR group(n=24),with 60 min cardiac arrest by ACC followed by 30 min reperfusion,and cardioplegia used during the period of ACC;IPC group(n=24),with protocol similar to that of IR group except for three-round 15 min IPC applied before ACC;Poly B group(n=24),with protocol similar to that of IPC group except for polymyxin B administered after starting of IPC;PMA group(n=24),with protocol similar to that of IR group except for PMA administered before ACC.Membrane and cytosol fraction of PKC activity was assessed by biochemical assays,and myocardial Ca~(2+)content was determined simultaneously.RESULTS PKC activity in both membrane and cytosol fractions was significantly reduced after 60 min cardiac arrest with ACC and during myocardial reperfusion in IR group while the Ca~(2+)content in myocardium was significant increased.However,IPC enhanced the activation and translocation of PKC to the membrane and significantly reduced the rise in myocardial Ca2 +content.Although mem-brane and cytosol fraction of PKC activity were also both inhibited by Poly B after ACC,the increase ofmyocardial Ca2 +contentwas markedly attenuated which was comparable with thatin IPC group,whereasthe change patterns of PKC activities and myocardial Ca2 +content were similar to IPC in PMA group.CONCLUSION Cardioprotection by IPC is mediated through enhanced translocation of PKC to the membrane.PKC in-hibitor Poly B cannot completely abolish IPC-induced cardioprotection.PKC activator PMA mimics at least partially theprotective effect of IPC against myocardial calcium overload." @default.
- W2393559092 created "2016-06-24" @default.
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- W2393559092 date "2006-01-01" @default.
- W2393559092 modified "2023-09-26" @default.
- W2393559092 title "Role of Protein kinase C in the Protection of Ischemic Preconditioning on the Myocardial Ischemia and Repurfusion Injury in Cat Heart" @default.
- W2393559092 hasPublicationYear "2006" @default.
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