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- W2393561088 abstract "Objective: To prepare famotidine injection,establish its quality control and determine its stability and safety. Methods: Some work was done to optimize the prescription and preparation technology. The character, identification and examination et al were tested.The content and the related materials of famotidine injection were determined by HPLC.Stress testing, accelerated testing and long-term testing were done to study its stability. The safety was evaluated by testing the vessel stimulation, haemolyticus and hypersensitivity.Results:The method had an effective separation of the main component from impurities which produced after a series of destruction test,such as acid, alkalization,oxidation,light and thermal destruction.The detective limit was 1.0 ng. The linear relation of famotidine was excellent within the range of 80.32-120.48 μg/ml, and the average recovery rate was 99.76% with RSD was 0.73%. No obvious changes were observed at 6 month of an accelerated test or 12 month of long-term storage test. Conclusion: The preparation is reasonable in formulation, simple and convenient in preparation technique, accurate in quality control, good in stablility, and safe in application." @default.
- W2393561088 created "2016-06-24" @default.
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- W2393561088 date "2010-01-01" @default.
- W2393561088 modified "2023-09-26" @default.
- W2393561088 title "The study of Famotidine Injection" @default.
- W2393561088 hasPublicationYear "2010" @default.
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