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- W2393571028 abstract "OBJECTIVE To study the bioequivalence of Pioglitazone orally disintegrating tablets in healthy volunteers.METHODS 18 healthy male volunteers were given a single oral dose of 10 mg Pioglitazone orally disintegrating tablets or reference Pioglitazone in a randomized cross-over study,plasma concentration of Pioglitazone was determined by HPLC.RESULTS The main pharmacokinetics of Pioglitazone in test and reference were listed as follows: Tmax were 2.08±0.88 h and 2.31±1.02 h,Cmax were 1.173±0.384 μg·ml-1 and 1.262±0.437 μg·ml-1,AUC0-24 were 9.816±3.040 μg·h·ml-1 and 10.513±3.288 μg·h·ml-1,AUC0-∞ were 11.032±3.745 μg·h·ml-1 and 11.509±3.486 μg·h·ml-1,respectively.CONCLUSIONS The results of statistics analysis show that two preparations were bioequivalent." @default.
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- W2393571028 date "2007-01-01" @default.
- W2393571028 modified "2023-09-23" @default.
- W2393571028 title "Bioequivalence of Pioglitazone orally disintegrating tablets in healthy volunteers" @default.
- W2393571028 hasPublicationYear "2007" @default.
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