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- W2393582161 abstract "Objective:To investigate the effects of gross saponin from tribulus terrestris(GSTT)on lung ischemia-reperfusion injury in rats and its possible mechanisms.Methods:Thirty-two healthy male wistar rats were randomly divided into four groups:C group,IR group,L group,H group.After 120 min reperfusion,measurining the contents of malondialdehyde(MDA)and activity of superoxide dismutase(SOD)in plasma,the wet/dry(W/D)lung ratio and the activity of myelope-roxidase(MPO)in lung tissue and lung tissue histopathological changes were determined by the microscope.Results:In IR group,after 120 min reperfusion,the contents of MDA in plasma,the W/D lung ratio and the activity of MPO in lung tissue were all significantly increased,while the activity of SOD in plasma were lower than other groups.Pretreamented by GSTT,both lower or high does can attenuate the I/R induced abnormal changes.Histopathological examination showed that the I/R induced injury was also ameliorated by GSTT pretreament.Conclusion:GSTT treatment before ischemia could protect the lungs against the I/R induced injury by inhibiting the PMN infiltration and reducing the formation of oxyradical." @default.
- W2393582161 created "2016-06-24" @default.
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- W2393582161 date "2008-01-01" @default.
- W2393582161 modified "2023-09-26" @default.
- W2393582161 title "The protective effects of gross saponin from tribulus terrestris on lung ischemia-reperfusion injury in rats" @default.
- W2393582161 hasPublicationYear "2008" @default.
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