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- W2393598052 abstract "Objective To explore the neuronal apoptosis and its relationship to the expression of Bcl-2 and Caspase-3 genes after focal cerebral ischemia reperfusion in rats.Methods The variations of apoptosis on the different time points after focal cerebral ischemia reperfusion were observed with terminal deoxynucleotidyl tranferase mediated dUTP-flourescein nick end-labeling (TUNEL) assay. The expression of Bcl-2 mRNA and Caspase-3 mRNA was determined by in situ hybridization.Results (1) TUNEL-positive cells were located in the inner boundary zone of the infarction and progressively increased and peaked at 24 h after reperfusion, then decreased at 2 d. But the numbers of apoptosis cells were still in high level after 14 h compared with sham-operated group. (2) The expression of Bcl-2 mRNA began at 2 h after reperfusion, peaked at 12 h~24 h, and then decreased at 2 d. The time-phase pattern of Bcl-2 was similar to that of apoptosis. (3) The expression of Caspase-3 mRNA reached a peak at 24 h after reperfusion. The temporal and spatial profile of Caspase-3 mRNA expression was consistent with that of Bcl-2 mRNA.Conclusions The neuronal apoptosis after focal cerebral ischemia reperfusion was a dynamic ongoing process. The expression of Bcl-2 might inhibit apoptosis. Caspase-3 might play a key role in neuronal apoptosis of ischemic brain injury." @default.
- W2393598052 created "2016-06-24" @default.
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- W2393598052 date "2003-01-01" @default.
- W2393598052 modified "2023-09-22" @default.
- W2393598052 title "The neuronal apoptosis and its relation to the expression of Bcl-2 and Caspase-3 after focal cerebral ischemia reperfusion in rats" @default.
- W2393598052 hasPublicationYear "2003" @default.
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