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- W2393601295 abstract "Objective To investigate the effect of RGC-32 in cell proliferation and apoptosis of pancreatic cancer cell line Bx PC-3. Methods Pancreatic cancer cell line Bx PC-3 was routinely cultured. RGC-32 expression plasmid pc DNA3. 1 / myc-His C-RGC-32 was constructed transiently trasfected into Bx PC-3 cells to overexpress RGC-32 and used as experimental group. Emptly vector( pc DNA3. 1 / myc-His C) was used as a negative control. Quantitative reverse transcription-PCR( qRT-PCR) and western blotting was performed to determine the transfection efficiency. Cell counting kit-8( CCK-8) and flow cytometry were used to determine the influence of RGC-32 on cell proliferation and apoptosis of Bx PC-3 cells respectively. Results QRT-PCR and western blotting demonstrated that the expression level of RGC-32 in experimental group was significantly higher than control group at both mRNA and protein levels. CCK-8 showed that the cell proliferative vitality rate in experimental group was significantly lower than that control group. Cell apoptosis detection showed that there was no difference in apoptosis rate between experimental group and control group. Conclusion RGC-32 overexpression inhibits the proliferation of Bx PC-3 cells,but has no obvious effect on cell apoptosis." @default.
- W2393601295 created "2016-06-24" @default.
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- W2393601295 date "2014-01-01" @default.
- W2393601295 modified "2023-09-23" @default.
- W2393601295 title "Influence of RGC-32 overexpression on proliferation and apoptosis of pancreatic cancer cell line Bx PC-3" @default.
- W2393601295 hasPublicationYear "2014" @default.
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