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- W2393605143 abstract "OBJECTIVE:To prepare Nimesulide(Nim)inclusion complex with highly soluble β-cyclodextrin derivative sulfopropylether-β-cyclodextrin(SPE7-β-CD)and confirm the molar ratio of two components.METHODS:Equimolar series method was used in the first place,keeping the total molar concentration consistent;Nim and SPE7-β-CD were prepared in varying proportions(1:3,1:2,2:3,1:1,3:2,2:1,3:1).The difference(ΔA)between absorbance of varieties solution and absorbance of Nim was analyzed.The phase solubility curves of Nim inclusion complex including different concentrations(0.2×10-4,0.4×10-4,0.6×10-4,0.8×10-4,1×10-4 mol/L)of SPE7-β-CD with different pH value(5.45,6.82,7.68)were analyzed.Finally,UV scanning was conducted.The absorbance difference between adjacent curves were calculated at 393 nm to determine the molar ratio.RESULTS:The molar ratio of SPE7-β-CD to Nim was 1:1 when ΔA reached the maximum;under different pH,phase solubility of Nim increased with gradient sign as the increase of SPE7-β-CD concentration,showing AL type;it indicated that molar ratio of SPE7-β-CD to Nim was 1:1.Results of UV scanning showed that ΔA of Nim between adjacent curves at 393 nm were equal,indicating molar ratio of SPE7-β-CD to Nim was 1:1.CONCLUSIONS:SPE7-β-CD and Nim can form soluble inclusion complex with molar ratio of 1:1." @default.
- W2393605143 created "2016-06-24" @default.
- W2393605143 creator A5084643092 @default.
- W2393605143 date "2013-01-01" @default.
- W2393605143 modified "2023-09-26" @default.
- W2393605143 title "Selection of Molar Ratio of Two Components in Nimesulide/Sulfopropylether-β-cyclodextrin Inclusion Complex" @default.
- W2393605143 hasPublicationYear "2013" @default.
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