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- W2393606472 abstract "Objective To investigate whether the elevated plasma total homocysteine (tHcy) increases the risk of coronary heart disease (CHD) in Chinese. Methods The plasma levels of tHcy, lipid and glucose were analysed in 2000 patients underwent coronary angiography, 1698 of the 2000were,diagnosed as CHD, 302,non-CHD, and 500 sex- and age- matched healthy subjects as control. Conventional risk factors for CHD were recorded as well. Results (1) The plasma tHcy level and incidence (%) of hyperhomocysteinemia were significantly higher in CHD group [male: 16.43±1.60μmol/L, (51.3%) ; female: 14.38±1.51μmol/L, (39.3%)] than non-CHD group [male:13.70±1.49μmol/L (34.1%) ; female: 12.27±1.39μmol/L (22.0%)] and normal controls [male:12.37±1.32μmol/L (24.7%) ; female: 10.65±1.31μmol/L (10.0%)] (P0.001) . Patients with CHD were subgrouped into acute myocardial infarction (AMI) , old myocardial infarction (OMI) and angina pectoris (AP) groups, The level of tHcy was much higher in AMI group than OMI and AP groups ( P0.001) . Patients with CHD also had more traditional risk factors ( TC, LDL-C and smoking, family history of CHD, hypertension and diabetes and lower HDL-C ) than those of non-CHD group and normal controls.Male subjeccts had higher tHcy than that of female subjects (P0.01) . A positive correlation between plasma tHcy levels and age was present in the men in normal controls and in the women in CHD group (r=0.258, P0.001 and r=0.129, P 0.05) .The tHcy level was negatively correlated with glucose level (P0.02) , but not lipid levels. Multiple stepwise logistic regression analysis showed that tHcy were still significantly associated with CHD after adjusted the conventional risk factors, Compared with the normal controls, the odds ratio was 6.57 (95%CI: 4.24-10.19, P0.001) and 3.95 (95%CI: 2.79-5.59, P0.001) for the AMI group and OMI group, respectively, AMI group OMI group AP group. Conclusion Population in China had higher prevalence rate of hyperhomocysteinemia than some western countries.hyperhomocysteinemia is an independent risk factor for CHD, especially for myoeardial infarction in Chinese, and the degree of increased level of tHcy is consistent with the severity of the" @default.
- W2393606472 created "2016-06-24" @default.
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- W2393606472 date "2003-01-01" @default.
- W2393606472 modified "2023-09-25" @default.
- W2393606472 title "Plasma homocysteine Associated with Coronary Heart Disease in Chinese" @default.
- W2393606472 hasPublicationYear "2003" @default.
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