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- W2393619796 abstract "Objective To evaluate the inhibitory effectiveness of 8-chloroadnosine on experimental retinal neovascularization by local injection. Design Experimental study.Participants 40 rabbits.Methods Retinal vein occlusion model was created with direct laser photocoagulation to retinal veins of 40 eyes of rabbits.Twenty eyes were selected in each group of normal salt solution control and 8-chloroadnosine treated groups.8-Cl-A 0.3ml(9mg)or same volume of normal salt solution a day was given by retrobulbar injection (total 10 days),and the inhibitory effect on retinal neovascularization was recorded with fundus fluorescein angiography after 2 weeks of injection.Main Outcome Measures The incidence and its level of experimental retinal neovascularization.Results Retinal neovascu- larization was found in 17 eyes of control group,and in 3 eyes of 8-chloroadnosine treated group(P=0.000),which was much less prominent compared with that of the control group.No retinal collateral vessels were detected.Conclusion 8-chloroadnosine is effective in the inhibition of experimental retinal neovascularization of rabbits,which implies its potential clinical value in the treatment of retinal proliferative vasculopathy." @default.
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- W2393619796 date "2007-01-01" @default.
- W2393619796 modified "2023-09-27" @default.
- W2393619796 title "Inhibition study of 8-chloroadnosine on experimental retinal neovascularization" @default.
- W2393619796 hasPublicationYear "2007" @default.
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