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- W2393644346 abstract "Objective:To reveal the relationship between cell spreading and DR5 distribution on the cell surfaces of human esophageal carcinoma EC9706 cell line.Methods:DR5 distribution of EC9706 cells was observed under fluorescence microscope by immunocytochemical assay. DR5 expression on EC9706 cell surfaces and EC9706 cell apoptosis were detected by flow cytometry analysis.Results:DR5 primarily was located in the cytoplasm and on the surfaces of EC9706 cells, mainly in the cytoplasm but not in the nuclei. DR5 expression on the surfaces of the floating cells was much higher than of the spreading cells, in addition, the floating cells were more sensitive to the apoptosis induced by anti-DR5 agonistic antibody mDRA-6 than the spreading cells.Conclusion:There is a close relationship between DR5 expression on the surfaces of EC9706 cells and the cell spreading, and the cell spreading maybe have an important effect on DR5 expression on the cell surfaces and on the sensitivity of the cells to the apoptosis induced by antibody mDRA-6 or TRAIL. The results maybe provide new insights into the regulation mechanisms of DR5 expression and distribution on cell surfaces, and also provide potential instruction significance for future clinical application of antibody mDRA-6 and TRAIL." @default.
- W2393644346 created "2016-06-24" @default.
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- W2393644346 date "2006-01-01" @default.
- W2393644346 modified "2023-09-25" @default.
- W2393644346 title "The relationship between DR5 expression on the surfaces of esophageal carcinoma cells and cell spreading" @default.
- W2393644346 hasPublicationYear "2006" @default.
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