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- W2393644925 abstract "Objective To study the expression of aminoglutaminic acid transporter(EAAT) mRNA in cerebral cortex of diabetic rats having brain injury and its potential mechanism.Method Twenty-eight Wistar rats were randomly divided into two groups:14 rats fed with normal diet were selected as control group,and 14 rats fed with high glucose and high fatty diet plus intraperitoneal injecting STZ for inducing insulin resistance were selected as model group.Rats of two groups were free water-intake and illumination was given for 12h.One month late,blood glucose was measured.After 6 months,and EAAT-1,EAAT-2 and EAAT-3 mRNA expressions in cerebral cortex were detected by RT-PCR.Results The blood glucose level in model group[(20.016±1.984)mmol/L)]was higher than normal value(P0.01) and that in control group[(3.82±0.123)mmol/L,P0.01],The islet cells decreased significantly in pancreatic tissue in model group,while a lot of islet cells were observed in control group.The expression of EAAT-3 mRNA in model group was higher than that in control group(P0.01).Conclusions The up-regulate expression of EAAT-3 could be an important factor in brain injury of rats with diabetes mellitus." @default.
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- W2393644925 date "2012-01-01" @default.
- W2393644925 modified "2023-09-26" @default.
- W2393644925 title "Expression of EAAT mRNA in cerebral cortex of diabetic rats with brain injury" @default.
- W2393644925 hasPublicationYear "2012" @default.
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