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- W2393654173 abstract "Effects of benzoapyrene(BaP)exposure on the activity of glutathione S -transferase(GST)in black porgy (Sparus macrocephalus)liver was studied. The dose and time response of two enzymes (7-ethoxyresorufin O -deethylase (EROD) and GST)involved in BaP metabolism and the amounts of BaP metabolites excreted into the bile were investigated. Results showed that the time -response trend on of induction of hepatic GST of black porgy was bell -shaped with a plateau at BaP exposure for 2 days. A significant dose-related increase of the GST activity in liver was observed at the exposure time of 12h, 1d and 2d (R12h=0.966, p0.05; R1d=0.9529, p0.05; R2d=0.824, p0.05). Compared with our former study, the induction of hepatic EROD, GST activities and biliary 3-OH BaP of black porgy were significantly induced by BaP (0.5, 1.0, 2.0 and 5.0μg·L-1)after exposure for 7 days and a significant dose -response relationship between 3-OH BaP and BaP was observed(R=0.943, p0.05). After exposed to 2.0μg·L-1 BaP, similar variation trends of hepatic EROD, GST activities and biliary 3-OH BaP had been observed in black porgy, but those variations were not consistency with the time change completely. Those results demonstrated that the variation between hepatic metabolic enzymes and biliary metabolites were very complex. The exposure concentrations and exposure time were the most important factors which influence the variations of metabolic enzymes and metabolites." @default.
- W2393654173 created "2016-06-24" @default.
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- W2393654173 date "2009-01-01" @default.
- W2393654173 modified "2023-09-24" @default.
- W2393654173 title "Effects of Benzoapyrene Exposure on Hepatic GST Activity in Black Porgy(Sparus macrocephalus)and Variation Relationships with Hepatic Metabolic Enzymes and Biliary Metabolites" @default.
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