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- W2393662711 abstract "Objective To investigate the expressions of leptin,leptin receptor(OB-Rb) and vascular endothelial growth factor(VEGF) in tissue of non-small cell lung cancer,and their relationgship with the clinicopathological features and prognosis.Methods The immunohistochemistry PV-6000 was applied to detect the expressions of leptin,OB-Rb and VEGF in 30 NSCLC tissues and their adjacent normal lung tissues,the relationship of their expressions with the clinicopathological features and prognosis was analyzed by spearman rank correlation and COX regression.Results In NSCLC tissues,the positive rates of leptin,OB-Rb and VEGF expression were 70%,73.3% and 93.3%,respectively.The expressions of leptin,OB-Rb and VEGF in NSCLC tissues were significantly higher than that in adjacent normal lung tissues(P0.05).The expressions of leptin,OB-Rb and VEGF had no correlation with gender,histological subtypes,lymph node metastasis or TNM staging in NSCLC tissues(P0.05).There was a significant correlation between leptin and OB-Rb expression in NSCLC(P0.05),there was also a significant correlation between OB-Rb and VEGF(P0.05).TNM staging and leptin were independent prognostic factors.Conclusions The research indicates that after the binding of leptin and OB-Rb,the VEGF expression was up-regulated through signal transduction,thus promoting the vascular generation in NSCLC.Leptin and TNM staging are independent factors affecting the prognosis of NSCLC patients." @default.
- W2393662711 created "2016-06-24" @default.
- W2393662711 creator A5008723194 @default.
- W2393662711 date "2011-01-01" @default.
- W2393662711 modified "2023-09-26" @default.
- W2393662711 title "Expression and clinical significance of Leptin,OB-Rb,VEGF in tissue of NSCLC" @default.
- W2393662711 hasPublicationYear "2011" @default.
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