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- W2393672005 abstract "Objective To determine the subacute toxicity of [2,3,5,6-Tetrafluoro-4-(methoxymethyl)phenyl] methyl 2,2-dimethyl-3-(3,3,3-trifluoro-1-propenyl) cyclopropanecarboxylate(TPMDC) inhaled by rats for 28 days.Methods SPF SD rats were randomly divided into 4 groups with 12 rats in each group,6 females and 6 males.The animals inhaled with TPMDC at the concentration of 0,0.58,1.70 and 6.48 mg/m3 for 4 weeks(4 h/d,5 d/w),respectively.At the end of the test,blood samples were collected for analysis of complete blood count and serum biochemical indexes.The main organs were weighed and pathological changes were observed.Results In both medium and high concentration groups(1.70 and 6.48 mg/m3) exposed to TPMDC,poisoning symptoms were observed including trembling,blood-like-secretion around mouth and nose.Compared with the control group,it was found that white blood cell(WBC) of female rats decreased.Body weight decreased in high concentration group,while the percentage of basophilic granulocyte reduced,kidney ratio(kidney weight/body) increased in male rats and AKP level increased in female rats.Conclusion The results suggested that the non-observed adverse effect level(NOAEL) of TPMDC in SD rats was 0.58 mg/m3(4 h/d for 28 days)." @default.
- W2393672005 created "2016-06-24" @default.
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- W2393672005 date "2010-01-01" @default.
- W2393672005 modified "2023-09-27" @default.
- W2393672005 title "Experimental research on subacute toxicity of rats inhaled[2,3,5,6-tetrafluoro-4-(methoxymethyl)phenyl] methyl 2,2-dimethyl-3-(3,3,3-trifluoro-1-propenyl) cyclopropanecarboxylate" @default.
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