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- W2393677892 abstract "To study the effect of difluromethyl ornithine ( DFMO) on cell growth and expression of the asso-ciated genes of human lung carcinoma L 78. Methods:The cell growth curves, teleomerase activity, morphological ob-servation and DNA electrophoresis were used for assess of the cell growth rate and cell apoptosis, respectively. The gene expression was detected with Northern Blot and immunocytochemical technique. Results:1. The growth of L 78 cells treated with DFMO were inhibited, while the number of the cell apoptosis increased in comparison with control cells. 2. The expression of of 4 in DFMO-treated L 78 cells was induced, in that time, the down-regulated expression of P 21ras genes and the up-regulated expression of Fas gene were detected. Conclusion: DFMO could inhibit the growth and induce the apoptosis of L 78 cells. It would be associated with the induced expression of of 4 gene, by which the expression of P 21ras and Fas gene was regulated." @default.
- W2393677892 created "2016-06-24" @default.
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- W2393677892 date "2004-01-01" @default.
- W2393677892 modified "2023-09-23" @default.
- W2393677892 title "Growth inhibition, apoptosis induction and expression regulation of associated genes of the tumor cells L78, treated with DFMO" @default.
- W2393677892 hasPublicationYear "2004" @default.
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