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- W2393686711 abstract "[Objective]To study the polymorphisms of the apolipoprotein AI-CⅢ-AIV gene cluster in gout with insulin resistance and explore the impact of the ApoAI-CⅢ-AIV gene cluster on hyperlipidemia in gout with insulin resistance.[Methods]The cases in gout and gout with insulin resistance were from 5 hospitals in Shandong province during February-December,2008,and selecting healthy volunteers who undergowent a medical examination in the hospital in the identical time as a control.Three groups had no significant difference in age,gender etc.by statistical analysis.PCR-RFLP and biochemistry methods were used to explore the distribution of different genotypes and gene frequencies of ApoAI-CⅢ-AIV gene cluster,to investigate the correlation between the gene mutation and blood lipids,and analyze the relationship between hyperlipidemia in gout with insulin resistance and ApoAI-CⅢ-AIV gene cluster.[Results]The patients of gout with insulin resistance had a significantly higher serum levels of TC,TG and LDL-C;and higher serum concentrations of SUA,FBG and FNS compared with the subjects of gout and healthy volunteer(P0.05 or 0.01).The A allele at position-75 bp and the T allele at position +83 bp in the ApoAI-CⅢ-AIV gene cluster were more common in gout with insulin resistance than those in controls(P0.05).The X2 allele at Xmn I sites of ApoAI-CⅢ-AIV gene cluster was more in gout with insulin resistance than that in controls(P0.05).The levels of serum TG,HDL-C and apoAI in MspI 1 site with A/A genotyp were significantly higher than those with the genotype G/G(P0.05).The levels of serum TG in Xmn I site with X2X2 genotyp were higher than that with X1X1 genotype(P0.05).Higher levels of TG in gout with insulin resist-ance was result that the A allele at position MspI 1 and the X2 alele at Xmn I sites combined operations.[Conclusion] The genotype and allele change of the apolipoprotein AI-CIII-AIV gene cluster in gout with insulin resistance result in change of lipoprotein levels etc.It is related to combined operations of two genotypes.The results suggest that the ApoAI-CⅢ-AIV gene cluster is closely related to gout with insulin resistance.Prompted gout patients should actively prevent and control the development and interaction of the occurrence of the metabolic syndrome related diseases." @default.
- W2393686711 created "2016-06-24" @default.
- W2393686711 creator A5043682274 @default.
- W2393686711 date "2013-01-01" @default.
- W2393686711 modified "2023-09-27" @default.
- W2393686711 title "The Role of the Polymorphisms of the Apolipoprotein AI-CIII-AIV Gene Cluster for Hyperlipidemia in Gout with Insulin Resistance" @default.
- W2393686711 hasPublicationYear "2013" @default.
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