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- W2393686989 abstract "Objective: Since VEGF-A,C,D and their receptors had been identified to be associated with angiogenesis and lymphangiogenesis,the purpose of this study consists in:(1) to evaluate the relationship between VEGF-A,C,D and their receptor expression in tumor cells or tissues and tumor metastasis rate and path;(2) to explore whether VEGF-A,C or D can be used as parameters for predicting tumor metastasis.Methods: Two allograft and four human xenograft mouse subcutaneous tumor models were established to observe the tumor metastasis.Vascular-path metastasis was confirmed by tumor metastasis in the lung,liver and lymphatic-path metastasis was identified by tumor metastasis in lymph nodes.VEGF-A,C,D and their receptor VEGFR-2,VEGFR-3 and lymphatic endothe-lium marker,LYVE-1,in tumor cells and tumor tissues were detected by real-time RT-PCR and then correlated with tumor metastasis rate and path.Results: Among the six tumor models,the most common metastases took place in the lung and liver,accounting for 61%-100% and 16%-100%,respectively.The lymph node metastases were observed in two allograft mouse subcutaneous tumor models.Higher VEGF-A expression level was accompanied with more metastases in the lung and liver and more VEGF-C expression was also correlated with lymph node metastasis,but no correlation between VEGF-D and lymphatic metastasis was observed.Conclusion: VEGF-A plays a pivotal role in tumor vascular-path metastasis and VEGF-C is important to tumor lymphatic-path metastasis." @default.
- W2393686989 created "2016-06-24" @default.
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- W2393686989 date "2008-01-01" @default.
- W2393686989 modified "2023-09-26" @default.
- W2393686989 title "The relationship between angiogenesis and lymphangiogenesis-related genes expressions and tumor metastases" @default.
- W2393686989 hasPublicationYear "2008" @default.
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