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- W2393692664 abstract "AIM To observe the formation and effects of nitric oxide (NO) and free radicals on acute liver injury induced by thioacetamide (TAA). METHODS ①Twenty four rats were randomly divided into four groups: One normal control group and three hepatic injury groups. The animals of injury groups were injected one single dose of TAA 600mg/kg sc. The blood content of endotoxin and NO 3 -/NO 2 -, ALT, ALT and AST at 24, 48 and 72 hours were measured. The protein content, activity of SOD and GSHPX were measured in liver homogenates. Meanwhile, the liver morpho pathology was examined. ②Twenty four rats were divided into four groups, A B,C and D.Group A was normal. Animals in groups B, C and D were given TAA 600mg/kg sc to induce acute liver injury. The rats of group B were given normal saline 0 4mL/kg ;group C, 7 5% L Arg (300mg/kg); group D, 2 5% L NNA (10mg/kg);and it was repeated 24 hours later. After another 24 hour, the blood and liver tissue were obtained and the relevant parameters assayed the same as in experiment one. RESULTS After L Arg was injected into rats, the synthesis of NO was increased, and blood transaminase and liver injury degree were significantly decreased. In group of rats injected with L NNA, the degree of injury was serious, indicating that NO had protective effect against hepatic injury induced by TAA. The free radicals in liver tissue inhibited the synthesis of NO in hepatic injury. The content of LPO in liver was increased, and the activities of SOD and GSHPX were lower. So the cooperation of SOD and GSHPX may eliminate the free radicals in vivo . CONCLUSION The inhibited biological synthesis of NO and increased level of free radical can aggravate liver injury." @default.
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- W2393692664 date "1999-01-01" @default.
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- W2393692664 title "Effect of nitric oxide and free radicals on acute liver injury in rats" @default.
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