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- W2393693698 abstract "objective Skin Test Inhibition index(STⅡ) is an pharmacodynamic assay method to evaluate the curative effect of antihistamine which is reliable and sensitive. STⅡ was used to assess the onset time of acrivastine in this investigation. Method 27 subjects with hay fever in off-season were selected. Subjects were divided into acrivastine group (24) or placebo control group (3). Artemisia allergen skin test were carried out before and after treatment in 30、90 minutes. The wheal reactions were recorded and calculated. According to STⅡ method, the STⅡ value were computed. The time needed to reach STⅡ 10 was defined as the onset time. Result The wheal showed no significant changes in placebo controlled subjects. The wheal size induced by Artemisia pollen extract where significantly inhibited after acrivastine treatment. The STⅡ were 22.2 and 237.7 after acrivastine administration in 30、90 minutes respectively. Therefor the onest time of acrivastine was within 30 minutes. Conclusion STⅡ can be an objective index to evaluate the onset time of antihistamines." @default.
- W2393693698 created "2016-06-24" @default.
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- W2393693698 date "2004-01-01" @default.
- W2393693698 modified "2023-09-23" @default.
- W2393693698 title "Evaluation on onset time of acrivastine assayed with skin test inhibition index" @default.
- W2393693698 hasPublicationYear "2004" @default.
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