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- W2393705280 abstract "Objective:To study the mechanism of anti-apoptosis and changed expression of Bcl-xl/s in ischemic postconditioning (PostC) in rats. Methods: Eighteen healthy adult male Wistar rats were divided into three groups including Sham group, ischemia-reperfusion (I/R) group and PostC group (n=6 for each). TUNEL staining was used to analyse the myocardial apoptotic index. Immunohistochemisty was used to detect the protein level of Bcl-xl/s. The expressions of Bcl-xl mRNA and Bcl-xs mRNA were determined by real-time PCR. Results: Compared with I/R group, the cardiomyocyte apoptotic index significantly decreased, the expression of Bcl-xl protein and Bcl-xl mRNA increased in PostC group. The expressions of Bcl-xs protein and Bcl-xs mRNA decreased significantly in PostC group than those of I/R group. Conclusion: PostC can significantly decrease the cardiomyocyte apoptosis after I/R injury, in which Bcl-xl and Bcl-xs mRNA involved in I/R-induced myocardial apoptosis." @default.
- W2393705280 created "2016-06-24" @default.
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- W2393705280 date "2011-01-01" @default.
- W2393705280 modified "2023-09-28" @default.
- W2393705280 title "Effects of Ischemic Postconditioning on Cardiomycyte Apoptosis and Expression of Bcl-xl/s in Rats" @default.
- W2393705280 hasPublicationYear "2011" @default.
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