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- W2393710852 abstract "Objective To explore the clinical and laboratory features,chemotherapy responses and long-term survival of multiple myeloma in patients younger than 40 years.Methods The clinical data of 230 cases of newly diagnosed myeloma patients admitted to the First Affiliated Hospital of Sun Yat-sen University from Jan.2000 to Sep.2007 were analyzed retrospectively.Results There were 24(10.4%)of 230 patients younger than 40 when diagnosed.Compared with the patients older than 40,the main myeloma type of younger patients was also mainly IgG(54.2% vs 45.1%),but younger patients had fewer IgA type(4.2% vs 21.8%),more solitary and extramedullary myeloma(12.5% vs 1.9%),P=0.009.The younger patients had higher extramedullary infiltration rate(23.8% vs 3.0%,P0.001),lower serum β2-MG level(P=0.032)and fewer patients with albumin lower than normal level(P=0.023).The two groups had similar partial responsive rate(69.2% vs 55.6%,P=0.355)to chemotherapy.The patients younger than 40 had longer median overall survival than elder patients(39.6 months vs 29.3 months),but there had no statistical difference(P=0.280).It seems that the younger patients with extramedullary infiltration had poor responses to chemotherapy and shorter survival.Conclusion The incidence of younger myeloma patients in China is higher than abroad.Younger patients should receive high dose chemotherapy followed by haemopoietic stem cell transplant as early as possible,especially those with extramedullary infiltration." @default.
- W2393710852 created "2016-06-24" @default.
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- W2393710852 date "2008-01-01" @default.
- W2393710852 modified "2023-09-23" @default.
- W2393710852 title "Clinical features and survival of myeloma patients younger than 40 years." @default.
- W2393710852 hasPublicationYear "2008" @default.
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