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- W2393720907 abstract "Aim According to the targets of 5-HT transporter and 5-HT2A receptor,a series of N-indolalkyl piperidine derivatives and their analogues were synthesized and tested for their biological activities.Methods Eighteen compounds were prepared from benzo-fused nitrogen heterocycles through N-alkylation and then condensation with derivatives of piperidine or piperazine.All of them were carried out in vitro pharmacological test for the 5-HT transporter and 5-HT2A receptor.Among the tested compounds 10c and 10e were trialed analgesic activities in both mice writhing and mice hot plate models.Results and conclusion Eighteen novel compounds were prepared,and their structures were confirmed by 1H-NMR and HRMS.Most of them showed high affinity for the 5-HT transporter and 5-HT2A receptor.10c and 10e exhibited potent analgesic activities in two models in vivo with low affinity to μ,δ,κ receptors,which is a chance to find a better precursor of non-opioid analgesic for further optimization." @default.
- W2393720907 created "2016-06-24" @default.
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- W2393720907 date "2009-01-01" @default.
- W2393720907 modified "2023-09-23" @default.
- W2393720907 title "Synthesis and biological activities of N-indolalkyl piperidine derivatives and their analogues" @default.
- W2393720907 hasPublicationYear "2009" @default.
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