Matches in SemOpenAlex for { <https://semopenalex.org/work/W2393724222> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2393724222 abstract "[Objective]To investigate the apoptosis-inducing effect of Matrine(MA)on HT29cells and the underlying mechanism.[Methods] HT29cells were treated with MA of 0–16mg/ml concentration.The apoptosis was determined by annexin V-FITC/propidium iodide assay.The mitochondrial membrane potential(Δφm)was evaluated by flow cytometry with JC-1as probe.Protein levels were determined by western blot analysis and the role of caspase activities were assayed using caspase apoptosis detection kit.[Results]After treatment with MA,a decrease in the viability of HT29cells and increase in apoptosis were observed.MA-induced apoptosis was accompanied by loss of mitochondrial membrane potential.Meanwhile,the anti-apoptotic protein Bcl-2level was down-regulated,whereas,the pro-apoptotic protein Bax level up-regulated.MA increased the activity of caspase-9and caspase-3.[Conclusion]These results indicate that MA can induce the apoptosis of HT29cell lines in a dose-dependent manner,which is probably mediated by mitochondrial apoptosis pathway." @default.
- W2393724222 created "2016-06-24" @default.
- W2393724222 creator A5033902972 @default.
- W2393724222 date "2013-01-01" @default.
- W2393724222 modified "2023-09-25" @default.
- W2393724222 title "Matrine induces apoptosis of human colon cancer HT29 cells through mitochondrial pathway" @default.
- W2393724222 hasPublicationYear "2013" @default.
- W2393724222 type Work @default.
- W2393724222 sameAs 2393724222 @default.
- W2393724222 citedByCount "0" @default.
- W2393724222 crossrefType "journal-article" @default.
- W2393724222 hasAuthorship W2393724222A5033902972 @default.
- W2393724222 hasConcept C104317684 @default.
- W2393724222 hasConcept C153911025 @default.
- W2393724222 hasConcept C173358068 @default.
- W2393724222 hasConcept C181911157 @default.
- W2393724222 hasConcept C182979987 @default.
- W2393724222 hasConcept C185592680 @default.
- W2393724222 hasConcept C190283241 @default.
- W2393724222 hasConcept C2775934118 @default.
- W2393724222 hasConcept C2775998712 @default.
- W2393724222 hasConcept C2776415932 @default.
- W2393724222 hasConcept C2776545273 @default.
- W2393724222 hasConcept C28859421 @default.
- W2393724222 hasConcept C31573885 @default.
- W2393724222 hasConcept C43617362 @default.
- W2393724222 hasConcept C53009064 @default.
- W2393724222 hasConcept C553184892 @default.
- W2393724222 hasConcept C55493867 @default.
- W2393724222 hasConcept C75385678 @default.
- W2393724222 hasConcept C82381507 @default.
- W2393724222 hasConcept C85265743 @default.
- W2393724222 hasConcept C86803240 @default.
- W2393724222 hasConcept C88634738 @default.
- W2393724222 hasConcept C95444343 @default.
- W2393724222 hasConcept C98424977 @default.
- W2393724222 hasConceptScore W2393724222C104317684 @default.
- W2393724222 hasConceptScore W2393724222C153911025 @default.
- W2393724222 hasConceptScore W2393724222C173358068 @default.
- W2393724222 hasConceptScore W2393724222C181911157 @default.
- W2393724222 hasConceptScore W2393724222C182979987 @default.
- W2393724222 hasConceptScore W2393724222C185592680 @default.
- W2393724222 hasConceptScore W2393724222C190283241 @default.
- W2393724222 hasConceptScore W2393724222C2775934118 @default.
- W2393724222 hasConceptScore W2393724222C2775998712 @default.
- W2393724222 hasConceptScore W2393724222C2776415932 @default.
- W2393724222 hasConceptScore W2393724222C2776545273 @default.
- W2393724222 hasConceptScore W2393724222C28859421 @default.
- W2393724222 hasConceptScore W2393724222C31573885 @default.
- W2393724222 hasConceptScore W2393724222C43617362 @default.
- W2393724222 hasConceptScore W2393724222C53009064 @default.
- W2393724222 hasConceptScore W2393724222C553184892 @default.
- W2393724222 hasConceptScore W2393724222C55493867 @default.
- W2393724222 hasConceptScore W2393724222C75385678 @default.
- W2393724222 hasConceptScore W2393724222C82381507 @default.
- W2393724222 hasConceptScore W2393724222C85265743 @default.
- W2393724222 hasConceptScore W2393724222C86803240 @default.
- W2393724222 hasConceptScore W2393724222C88634738 @default.
- W2393724222 hasConceptScore W2393724222C95444343 @default.
- W2393724222 hasConceptScore W2393724222C98424977 @default.
- W2393724222 hasLocation W23937242221 @default.
- W2393724222 hasOpenAccess W2393724222 @default.
- W2393724222 hasPrimaryLocation W23937242221 @default.
- W2393724222 hasRelatedWork W1930282135 @default.
- W2393724222 hasRelatedWork W2007591319 @default.
- W2393724222 hasRelatedWork W2142367891 @default.
- W2393724222 hasRelatedWork W2147303798 @default.
- W2393724222 hasRelatedWork W2352900085 @default.
- W2393724222 hasRelatedWork W2355707334 @default.
- W2393724222 hasRelatedWork W2361394353 @default.
- W2393724222 hasRelatedWork W2368523882 @default.
- W2393724222 hasRelatedWork W2371139612 @default.
- W2393724222 hasRelatedWork W2372356089 @default.
- W2393724222 hasRelatedWork W2373490020 @default.
- W2393724222 hasRelatedWork W2378668064 @default.
- W2393724222 hasRelatedWork W2379597309 @default.
- W2393724222 hasRelatedWork W2382325980 @default.
- W2393724222 hasRelatedWork W2385739811 @default.
- W2393724222 hasRelatedWork W2388501386 @default.
- W2393724222 hasRelatedWork W2389272286 @default.
- W2393724222 hasRelatedWork W2393788118 @default.
- W2393724222 hasRelatedWork W2440549419 @default.
- W2393724222 hasRelatedWork W2474253747 @default.
- W2393724222 isParatext "false" @default.
- W2393724222 isRetracted "false" @default.
- W2393724222 magId "2393724222" @default.
- W2393724222 workType "article" @default.