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- W2393748559 abstract "Objective To observe expression of Survivin and cellular apoptosis in brain after MCAO and reperfusion in renovascular hypertensive rats.Methods Fifties renovascular hypertensive rats weighting 290～310 g without stroke were randomly divided into single ischemia-reperfusion groups and sham-operated group(25 each group). The middle cerebral artery occlusion (MCAO) was made by intraluminal vascular suture for 2h and reperfusion in the rats, but MCAO was not performed in sham-operated group. The cell counts of Survivin with immunohistochemical staining and the cellular apoptosis with TUNEL staining methods were measured, respectively, in coronal sections of brain after reperfusion (6, 12, 24, 48 and 72 hours).Results The Survivin protein had expressed at 6h after reperfusion, and its expresssion was intensified until 72h. The number of apoptotic cells increased with the development of reperfusion, and reached its the highest level at 72h. No positive cells of Survivin protein but 0～2 apoptotic cells could be discovered in brain section from sham-operated animals and in the opposoitive side to ischemia from the other groups animals.Conclusion Expression of Survivin protein increases and apoptosis exists after focal cerebral ischemia and reperfusion in rats' brain. Cerebral ischemia can enhance the expression of Survivin protein.Cellular apoptosis may contribute to the ischemic lesion." @default.
- W2393748559 created "2016-06-24" @default.
- W2393748559 creator A5031497837 @default.
- W2393748559 date "2005-01-01" @default.
- W2393748559 modified "2023-09-23" @default.
- W2393748559 title "The expression of Survivin and apoptosis after MCAO and reperfusion in renovascular hypertensive rats" @default.
- W2393748559 hasPublicationYear "2005" @default.
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