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- W2393749520 abstract "Objective: To investigate the synergistic effect of combination minocycline with anti-IL-6 on rats of spinal nerve liga-tion(SNL)-induced neuropathic pain.Methods: Before or after SNL-operation,100 μg minocycline were intrathecally injected.0.03 μg anti-IL-6 and the combination of two drugs were also injected after SNL-operation.The paw withdrawal latencies(PWL) of rats were ob-served.Results: ① Both preemptive-treatment and post-operation of minocycline could increase the PWL of SNL rats(P0.05),however,the PWL in preemptive-minocycline group was higher than that post-operation group(P0.05).② PWL in SNL-anti-IL-6 group in-creased compared with that in the SNL-saline group(P0.05),however,it was still decreased compared with sham-saline group(P0.05).③ PWL in combination group was increased compared with that in SNL-saline group(P0.05).④ PWL in combination group increased compared with that in SNL-anti-IL-6 group and SNL-post-minocycline group(P0.05).However,compared with SNL-preemp-tive-minocycline group,PWL in combination group was not significant different(P0.05).Conclusion: Combination minocycline with anti-IL-6 could exert significant analgesic effect on thermal hyperalgesia of neuropathic pain." @default.
- W2393749520 created "2016-06-24" @default.
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- W2393749520 date "2011-01-01" @default.
- W2393749520 modified "2023-09-24" @default.
- W2393749520 title "The Analgesic Effect of Combination Minocycline with IL-6 Neutralizing Antibody on Thermal Hyperalgesia Induced by Spinal Nerve Ligation in Rats" @default.
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