Matches in SemOpenAlex for { <https://semopenalex.org/work/W2393755937> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2393755937 abstract "Objective To explore the role of phosphatidylinositol 3-kinase(PI3K)signal pathway in insulin-induced proliferation promotion and apoptosis inhibition in endometrial cancer cells.Methods Endometrial cancer cell line Ishikawa3-H-12 was starve-cultured in serum-free medium.The cells were divided into different groups :control group,the group stimulated by insulin alone(Ins),the group preincubated with PI3K inhibitor LY294002 prior to insulin treatment(LY+Ins).We observed the proliferation and apoptosis of endometrial cancer cells by MTT assay and flow cytometric analysis.Results The absorbance at 570nm(OD570nm)in different groups at 24h,48h and 72h after treatment was measured.After insulin treatment,the OD570nm in these three time points were higher than the controls(all P0.01).However,OD570nm in LY+Ins group was lower than the group treated with insulin alone(P0.01).The apoptotic rate of Ins group was lower than the control[(2.02±0.39)% vs(14.46±2.70)%,P0.01].When co-treated with LY294002 and insulin,the apoptotic rate was higher than the group treated with insulin alone.Conclusion Proliferation promotion and apoptosis inhibition induced by insulin in endometrial cancer cells are mediated through PI3K signal pathway." @default.
- W2393755937 created "2016-06-24" @default.
- W2393755937 creator A5071367246 @default.
- W2393755937 date "2007-01-01" @default.
- W2393755937 modified "2023-09-24" @default.
- W2393755937 title "Role of phosphatidylinositol 3-kinase signal pathway in insulin-induced regulation of proliferation and apoptosis in endometrial cancer cells" @default.
- W2393755937 hasPublicationYear "2007" @default.
- W2393755937 type Work @default.
- W2393755937 sameAs 2393755937 @default.
- W2393755937 citedByCount "0" @default.
- W2393755937 crossrefType "journal-article" @default.
- W2393755937 hasAuthorship W2393755937A5071367246 @default.
- W2393755937 hasConcept C121608353 @default.
- W2393755937 hasConcept C126322002 @default.
- W2393755937 hasConcept C134018914 @default.
- W2393755937 hasConcept C16685009 @default.
- W2393755937 hasConcept C184235292 @default.
- W2393755937 hasConcept C190283241 @default.
- W2393755937 hasConcept C2776912716 @default.
- W2393755937 hasConcept C2777088508 @default.
- W2393755937 hasConcept C2779306644 @default.
- W2393755937 hasConcept C2780610907 @default.
- W2393755937 hasConcept C2780783641 @default.
- W2393755937 hasConcept C502942594 @default.
- W2393755937 hasConcept C55493867 @default.
- W2393755937 hasConcept C71924100 @default.
- W2393755937 hasConcept C86554907 @default.
- W2393755937 hasConcept C86803240 @default.
- W2393755937 hasConcept C95444343 @default.
- W2393755937 hasConceptScore W2393755937C121608353 @default.
- W2393755937 hasConceptScore W2393755937C126322002 @default.
- W2393755937 hasConceptScore W2393755937C134018914 @default.
- W2393755937 hasConceptScore W2393755937C16685009 @default.
- W2393755937 hasConceptScore W2393755937C184235292 @default.
- W2393755937 hasConceptScore W2393755937C190283241 @default.
- W2393755937 hasConceptScore W2393755937C2776912716 @default.
- W2393755937 hasConceptScore W2393755937C2777088508 @default.
- W2393755937 hasConceptScore W2393755937C2779306644 @default.
- W2393755937 hasConceptScore W2393755937C2780610907 @default.
- W2393755937 hasConceptScore W2393755937C2780783641 @default.
- W2393755937 hasConceptScore W2393755937C502942594 @default.
- W2393755937 hasConceptScore W2393755937C55493867 @default.
- W2393755937 hasConceptScore W2393755937C71924100 @default.
- W2393755937 hasConceptScore W2393755937C86554907 @default.
- W2393755937 hasConceptScore W2393755937C86803240 @default.
- W2393755937 hasConceptScore W2393755937C95444343 @default.
- W2393755937 hasLocation W23937559371 @default.
- W2393755937 hasOpenAccess W2393755937 @default.
- W2393755937 hasPrimaryLocation W23937559371 @default.
- W2393755937 hasRelatedWork W136039664 @default.
- W2393755937 hasRelatedWork W2014770830 @default.
- W2393755937 hasRelatedWork W2117739987 @default.
- W2393755937 hasRelatedWork W2140276460 @default.
- W2393755937 hasRelatedWork W2143946875 @default.
- W2393755937 hasRelatedWork W2155581263 @default.
- W2393755937 hasRelatedWork W2189632001 @default.
- W2393755937 hasRelatedWork W2352753912 @default.
- W2393755937 hasRelatedWork W2372230709 @default.
- W2393755937 hasRelatedWork W2378700414 @default.
- W2393755937 hasRelatedWork W2378882265 @default.
- W2393755937 hasRelatedWork W2380193234 @default.
- W2393755937 hasRelatedWork W2388221495 @default.
- W2393755937 hasRelatedWork W2393034918 @default.
- W2393755937 hasRelatedWork W2394416833 @default.
- W2393755937 hasRelatedWork W2395047971 @default.
- W2393755937 hasRelatedWork W2973141366 @default.
- W2393755937 hasRelatedWork W3028681590 @default.
- W2393755937 hasRelatedWork W3029882321 @default.
- W2393755937 hasRelatedWork W3093658369 @default.
- W2393755937 isParatext "false" @default.
- W2393755937 isRetracted "false" @default.
- W2393755937 magId "2393755937" @default.
- W2393755937 workType "article" @default.