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- W2393759898 abstract "Objective: To observe the expressions of PPARα,PPARγ in the livers of rats with Nonalcoho1ic Steatohepatitis(NASH) induced by high-fat diet,and on which the TFHL affects.Methods: The model rats of NASH had been induced by 12 weeks of high-fat diet,simultaneously,the model rats were treated with TFHL according to 250,125mg·kg-1·d-1,and with Essentiale according to 195.4mg·kg-1·d-1,the mRNA expressions of PPARα,PPARγ in the rat livers were detected with RT-PCR,the amounts of TNF-α,PPARα in the serum and livers of rats were detected with ELISA.Results: The expressions of the protein and mRNA of PPARα,and the expressions of PPARγ mRNA in the livers of model rats were obviously lowered than the normal,the amount of liver TNF-α was enhanced the normal.The expressions of PPARα mRNA showed negative correlation with the level of liver TNF-α.The inflammatory activity of rat liver and amount of TNF-α in rat liver in the TFHL high and low doses groups and Essentiale group were obviously lowered than the model.The expression of TNF-α gene mRNA,the amounts of serum and liver Leptin showed no difference.The expressions of PPARα protein and mRNA,and PPARγ mRNA in the livers of model rats were obviously enhanced than the model.Conclusion: PPARα and PPARγ take part in the injury process of Nonalcoho1ic fatty liver disease,maybe which is the principal mechanism of NASH onset.TFHL and Essentiale can protect liver and effectively prevent and treat NASH due to promoting the expressions of PPARα and PPARγ,and lowering the level of TNF-α." @default.
- W2393759898 created "2016-06-24" @default.
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- W2393759898 date "2012-01-01" @default.
- W2393759898 modified "2023-09-24" @default.
- W2393759898 title "Effect of TFHL on the expressions of PPARs in the livers of rats with nonalcoho1ic steatohepatitis" @default.
- W2393759898 hasPublicationYear "2012" @default.
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