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- W2393786712 abstract "Objective:To investigate whether brain surface cooling(BSC) can decrease cerebral content of water and Evans Blue(EB) after ischemia-reperfusion injury in experimental rabbits. Methods: Sixty-four male, adult and healthy New Zealand rabbits were randomly assigned to four groups. Group A, normal control group. Bilateral common carotid arteries of rabbits were exposed but not clipped and there was no BSC. Group B, ischemic control group. Bilateral common carotid arteries of rabbits were clipped and blood was taken out until a mean arterial pressure(MAP) of (45±2)mmHg reached. This condition was maintained for one hour, then brain blood flow and MAP were restored by loosing clips and transfusing blood for three hours. No BSC was used. Group C, low temperature normal saline group. 4 ℃ normal saline was continuously dripped to the surface of the brain through an opened hole of the skull at the onset of brain ischemia for four hours. Group D, room temperature normal saline group treated as same as in Group C except using 22-23 ℃ normal saline for BSC. EB was injected into vein to examine permeability of brain blood barrier at the onset of reperfusion. Brain EB and water content were measured. Results: Brain EB and water content were higher in Group B than in Group C and Group D(P0.05). There was no significant differences between Group C and Group D. Conclusion: BSC can decrease cerebral content of water and EB after ischemia-reperfusion injury in rabbits." @default.
- W2393786712 created "2016-06-24" @default.
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- W2393786712 date "2005-01-01" @default.
- W2393786712 modified "2023-09-26" @default.
- W2393786712 title "Effects of Brain Surface Cooling on Cerebral Content of Water and Evans Blue in Rabbits" @default.
- W2393786712 hasPublicationYear "2005" @default.
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