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- W2393786751 abstract "Objective To investigate the promoter methylation of apoptosis protease activating factor-1 (Apaf-1) and its association with the protein expression of enhancer of zeste homolog 2 (EZH2) in esophageal squamous cell carcinoma (ESCC). Methods The methylation-specific PCR (MSP) method was used to examine the methylation status of Apaf-1 in 128 ESCC patients, and immunohistochemistry method was used to detect the protein expression of Apaf-1 and EZH2 in tumors and corresponding normal tissues. Results The frequencies of Apaf-1 methylation in ESCC tumor tissues (52.3%, 67/128) were significantly higher than those in normal tissues (4.7%, 6/128) (P0.01), which was associated with TNM stage. The positive protein expression of Apaf-1 was significantly decreased in ESCC tumor tissues (41.4%, 53/128) compared with that of paired normal tissues (94.5%, 21/128) (P0.01). The positive protein expression of EZH2 was significantly increased in ESCC tumor tissues (72.7%, 93/128) than that of paired normal tissues (12.5%, 16/128) (P0.01). The protein expressions of Apaf-1 and EZH2 were associated with the TNM stage and pathological differentiation in ESCC patients (P0.01). The methylation status of Apaf-1 in ESCC was negatively correlated with the positive protein expression. The protein expressions of Apaf-1 and EZH2 were negatively correlated in ESCC. Conclusion Promoter hypermethylation of Apaf-1 and the higher protein expression of EZH2 may play important role in esophageal squamous cell carcinoma." @default.
- W2393786751 created "2016-06-24" @default.
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- W2393786751 date "2013-01-01" @default.
- W2393786751 modified "2023-10-04" @default.
- W2393786751 title "Promoter Methylation and Protein Expression of Apoptosis Protease Activating Factor-1 Gene in Esophageal Squamous Cell Carcinoma" @default.
- W2393786751 hasPublicationYear "2013" @default.
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