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- W2393787300 abstract "【Objective】To explore the protective effect of atorvastatin preconditioning on cerebral ischemia reperfusion injury in Sprague-Dawley rats and its mechanism.【Methods】 Forty-eight adult healthy male SD rats were randomly divided into control group,sham operation group,focal cerebral ischemia reperfusion group(FCIR)and atorvastatin preconditioning group(SS preconditioning).Before making a model,the rats in the SS preconditioning group were lavaged with atorvastatin 20 mg/kg,once a day for 10 consecutive days,and the same volume of the normal saline was lavaged for 10 consecutive days,in the sham operation and the FCIR groups.Middle cerebral artery occlusion reperfusion model was made by ligation decapitated method(ischemia for 2 hours,and reperfusion for 4 hours).After that,the animals were neurologically assessed on a 5 point scale,and then.The volume of infarction was measured by TTC staining,the expressions of Caspase-3 and Bcl-2 were detected by immunohistochemistry,and the number of neuron apoptosis was detected by TUNEL.【Results】 Compared with the control and sham groups,the infarction volume enlarged,the expressions of Caspasa-3 and Bcl-2 and the number of neuron apoptosis increased in the FCIR and the SS preconditioning groups(P0.01).Compared with the FCIR group,the volume of infarction was significantly reduced(P0.01),the neurological scores were improved(P0.05),the expression of Caspase-3 and the number of neuron apoptosis was significantly decreased(P0.05,P0.01),the expression of Bcl-2 was significantly increasedin SS preconditioning group(P0.05).【Conclusion】 The results suggested that simvastatin plays a protective role in focal cerebral ischemia reperfusion.The mechanism might be related to the increase in protein expression of Bcl-2 and the decrease in protein expression of Caspase-3,and the restrain of apoptosis." @default.
- W2393787300 created "2016-06-24" @default.
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- W2393787300 date "2011-01-01" @default.
- W2393787300 modified "2023-09-23" @default.
- W2393787300 title "Effects of atorvastatin preconditioning on the expressions of Caspase-3 and Bcl-2 in rats with focal cerebral ischemia reperfusion" @default.
- W2393787300 hasPublicationYear "2011" @default.
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