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- W2393799803 abstract "Objective: To establish a chiral precolumn derivatization method for optical purity test of L-Fudosteine. Methods: The enantiomers of D/L-Fudosteine were derivatized with ortho-phthalaldehyde/N-isobutyryl-L-cysteine (OPA/IBLC). The diastereoisomers produced were separated by reversed-phase high performance liquid chromatography on a Lichrospher C_ 18 column (250 mm×4.6 mm, 5 μm) with a mixture of 23 mmol/L acetate buffer (pH 6.0)-methanol-acetonitrile (60∶37∶3) as mobile phase at a flow rate of 1 mL/min and UV detection at 338 nm. Result: The derivatives of D/L-fudosteine were stable and well separated under the established HPLC conditions with the resolution factor being greater than 3.0. The method had very good sensitivity and repeatability for optical purity test of L-fudosteine with the limit of UV detection being about 40 μg/L (S/N = 3). Conclusion: The optical purity of L-fudosteine can easily be assessed by RP-HPLC method after being derivatized with ortho-phthalaldehyde/N-isobutyryl-L-cysteine (OPA/IBLC)." @default.
- W2393799803 created "2016-06-24" @default.
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- W2393799803 date "2005-01-01" @default.
- W2393799803 modified "2023-09-23" @default.
- W2393799803 title "Enantiospecific Analysis of Fudosteine by RP-HPLC with Chiral Precolumn Derivatization" @default.
- W2393799803 hasPublicationYear "2005" @default.
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