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- W2393822129 abstract "Objective: Experimental allergic encephalomyelitis (EAE), a T-cell mediated autoimmune disease, is widely considered as an animal model of multiple sclerosis. Various kinds of animals were used to induce EAE in order to search a domestic rat with high EAE incidence. Methods: Various kinds of animals were injected in 5 to 6 locations of the back of the body 0.5 ml with the guinea pig spinal cord in Freund's complete adjuvant and observed the clinical symptoms and histological alterations. Results:(1) The clinical symptoms of EAE of SD and Wistar rat occurred in two weeks after the rats were injected with antigens, the peak of the clinical symptoms and histological alterations on the 19th days.(2) The SD rat incidence of EAE was 13%, Wistar rat incidence of the disease was 30% and Kunming mouse incidence of the disease was 0%.(3) The Wistar rats without coming on EAE were secondly injected the antigen and observed for two months, EAE having still not occurrence.Conclusion: Wistar rat may be a fitter animal inducing EAE model in domestic usual experimental animals. The rat individual differences of EAE incidence may be mainly controlled by hereditary genes. [" @default.
- W2393822129 created "2016-06-24" @default.
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- W2393822129 date "2000-01-01" @default.
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- W2393822129 title "STUDY OF VARIOUS KINDS OF ANIMALS INDUCING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS" @default.
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